This is an abundantly illustrated resource for diagnosis of bone and soft tissue lesionsóa particular challenge due to their rarity and complexity. In addition to carefully selected histologic photographs, this unique atlas enhances standard visual information with illustrations of imaging findings, cytology, and molecular and cytogenetic information. This vivid pictorial survey is arranged in a pattern-oriented approach based on the actual working method used in daily practice.
The authors are expert educators in surgical and cytopathology and experienced diagnosticians in the complexities of soft tissue and bone pathology. This richly illustrated and concise reference will be a practical and indispensible tool for general pathologists and pathologists in training, who are required to diagnose bone and soft tissue pathologies. It is also an excellent resource for physicians seeking a quick survey of sarcoma.
Key Features:- Offers a practical, pattern-oriented diagnostic approach that mirrors the working method used in daily practice
- Augments histologic photographs with illustrations of imaging findings, cytology, and molecular and cytogenetic information
- Authored by recognized expert diagnosticians and teachers in the field
Tabella dei contenuti
Preface
Acknowledgments
PART I: OVERVIEW
1. Introduction
2. Principles of Diagnosis
2.1 Specimen Type and Procurement
2.2 Ancillary Testing
2.3 Tumor Grading and Staging
3. Clinical and Radiographic Features
3.1 Clinical Information
3.2 Imaging of Soft Tissue and Bone Tumors
Jamie T. Caracciolo
PART II: TUMORS OF SOFT TISSUE
4. Tumors With Adipose Differentiation
4.1 Lipoma With Variants
4.2 Spindle Cell/Pleomorphic Lipoma
4.3 Hibernoma
4.4 Lipoblastoma
4.5 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma
4.6 Dedifferentiated Liposarcoma
5. Tumors With Myxoid Stroma
5.1 Ganglion Cyst
5.2 Myxoma
5.3 Aggressive Angiomyxoma
5.4 Myxoid Liposarcoma
5.5 Extraskeletal Myxoid Chondrosarcoma
5.6 Myxofibrosarcoma (High Grade)
6. Benign and Low-Grade Spindle Cell Tumors
6.1 Fibromas
6.2 Elastofibroma
6.3 Fibromatosis
6.4 Neurofibroma
6.5 Schwannoma
6.6 Perineurioma
6.7 Nodular Fasciitis
6.8 Additional Variants of Fasciitis
6.9 Angiomyofibroblastoma
6.10 Cellular Angiofibroma
6.11 Myofibroblastoma
6.12 Gastrointestinal Stromal Tumor
6.13 Leiomyoma
6.14 Myofibroma and Myofibromatosis
6.15 Solitary Fibrous Tumor
6.16 Low-Grade Fibromyxoid Sarcoma
7. Intermediate- to High-Grade Spindle Cell Tumors
7.1 Leiomyosarcoma
7.2 Dermatofibrosarcoma Protuberans
7.3 Infantile Fibrosarcoma
7.4 Adult Fibrosarcoma
7.5 Malignant Peripheral Nerve Sheath Tumor
7.6 Spindle Cell/Sclerosing Rhabdomyosarcoma
7.7 Synovial Sarcoma
8. Epithelioid Soft Tissue Tumors
8.1 Rhabdomyoma
8.2 Granular Cell Tumor
8.3 Glomus Tumor
8.4 Neoplasms With Perivascular Epithelioid Cell Differentiation (PEComa)
8.5 Myoepithelial Tumors of Soft Tissue
8.6 Clear Cell Sarcoma
8.7 Epithelioid Sarcoma
8.8 Alveolar Soft Part Sarcoma
9. Small Round Blue Cell Tumors
9.1 Embryonal Rhabdomyosarcoma
9.2 Alveolar Rhabdomyosarcoma
9.3 Desmoplastic Small Round Cell Tumor
9.4 Extrarenal Rhabdoid Tumor
9.5 Melanotic Neuroectodermal Tumor of Infancy
10. Giant Cell-Rich Tumors
10.1 Plexiform Fibrohistiocytic Tumor
10.2 Tenosynovial Giant Cell Tumors
10.3 Giant Cell Tumor of Soft Tissue
11. Soft Tissue Tumors With Inflammation
11.1 Angiomatoid Fibrous Histiocytoma
11.2 Myxoinflammatory Fibroblastic Sarcoma
11.3 Inflammatory Myofibroblastic Tumor
11.4 Ig G4-Related Diseases
12. Vascular Tumors
12.1 Hemangiomas
12.2 Hemangioendothelioma
12.3 Kaposi Sarcoma
12.4 Angiosarcoma
13. Pleomorphic Soft Tissue Tumors
13.1 Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts
13.2 Pleomorphic Liposarcoma
13.3 Pleomorphic Myogenic Sarcomas (Rhabdomyosarcoma and Leiomyosarcoma)
13.4 Intimal Sarcoma
13.5 Undifferentiated/Pleomorphic Sarcoma
14. Soft Tissue Tumors With Osseous or Cartilaginous Matrix
14.1 Myositis Ossificans
14.2 Phosphaturic Mesenchymal Tumor
14.3 Tumoral Calcinosis
14.4 Synovial Chondromatosis
14.5 Ossifying Fibromyxoid Tumor of Soft Parts
14.6 Extraskeletal Osteosarcoma and Chondrosarcoma
PART III. TUMORS OF BONE
15. Osseous Lesions
15.1 Osteoma
15.2 Osteoid Osteoma
15.3 Osteoblastoma
15.4 Osteosarcoma
15.5 Major Histologic Variants of Osteosarcoma
15.6 Parosteal Osteosarcoma
15.7 Periosteal Osteosarcoma
16. Cartilaginous Lesions
16.1 Enchondroma
16.2 Osteochondroma and Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion)
16.3 Chondroblastoma
16.4 Chondromyxoid Fibroma
16.5 Chordoma
16.6 Chondrosarcoma
16.7 Clear Cell Chondrosarcoma
17. Giant Cell-Rich Lesions
17.1 Langerhans Cell Histiocytosis (Eosinophilic Granuloma)
17.2 Giant Cell Lesion of Small Bones (Giant Cell Reparative Granuloma)
17.3 Giant Cell Tumor of Bone
18. Spindle Cell Tumors
18.1 Fibrous Dysplasia
18.2 Nonossifying Fibroma
18.3 Osteofibrous Dysplasia
18.4 Adamantinoma
18.5 Desmoplastic Fibroma of Bone
18.6 Undifferentiated High-Grade Sarcoma of Bone
19. Small Round Blue Cell Tumors
19.1 Ewing Sarcoma and Primitive Neuroectodermal Tumor
19.2 Lymphoma of Bone
19.3 Plasmacytoma
19.4 Mesenchymal Chondrosarcoma
20. Cystic Lesions
20.1 Aneurysmal Bone Cyst
20.2 Simple Bone Cyst
Selected Readings
Index
Circa l’autore
Leslie G. Dodd, MD is Professor, Department of Pathology, Section Chief, Cytopathology, University of North Carolina, Chapel Hill, North Carolina.
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