Diabetes is now one of the major causes of morbidity worldwide. In
many cases, the onset of diabetes is progressive, developing via a
condition of insulin resistance. This book considers the
development of this condition, its consequences and clinical and
therapeutic aspects.
The book reviews the normal biology of insulin action on glucose,
lipids and proteins. It considers the pathological basis for
insulin resistance in animal models and humans, and discusses the
influence of heredity, dietary factors and exercise. Clinical
consequences including dyslipidaemia, hypertension and polycystic
ovary syndrome, and therapeutic strategies for treatment are also
examined.
* Provides an expert review of the phenomenon of insulin
resistance
* Brings together a host of recent research for the first
time
* Written by leading experts in biological and clinical research
Tabella dei contenuti
Preface.
List of Contributors
1. The Insulin Receptor and Downstream Signalling (Ken
Siddle).
2. Insulin-Mediated Regulation of Glucose Metabolism (Daniel
Konrad, Assaf Rudich and Amira Klip).
3. Insulin Action on Lipid Metabolism (Keith N. Frayn and
Fredrik Karpe).
4. The Effect of Insulin on Protein Metabolism (Laura J. S.
Greenlund and K. Sreekumaran Nair).
5. Genetically Modified Mouse Models of Insulin Resistance
(Gema Medina, Christopher Lelliott and Antonio J.
Vidal-Puig).
6. Insulin Resistance in Glucose Disposal and Production in Man
with Specific Reference to Metabolic Syndrome and Type 2 Diabetes
(Henning Beck-Nielsen, Frank Alford and Ole
Hother-Nielsen).
7. Central Regulation of Peripheral Glucose Metabolism
(Stanley M. Hileman and Christian Bjørbæk).
8. Relationship Between Fat Distribution and Insulin Resistance
(Philip G. Mc Ternan, Aresh Anwar and Sudhesh Kumar).
9. PPARy and Glucose Homeostasis (Robert K.
Semple and Stephen O’Rahilly).
10. Adipokines and Insulin Resistance (Daniel K. Clarke and
Vidya Mohamed-Ali).
11. Dietary Factors and Insulin Resistance (Jeremy Krebs and
Susan Jebb).
12. Physical Activity and Insulin Resistance (Nicholas J.
Wareham, Søren Brage, Paul W. Franks and Rebecca
Abbott).
13. Genetics of the Metabolic Syndrome (George Argyropoulos,
Steven Smith and Claude Bouchard).
14. Insulin Resistance and Dyslipidaemia (Benoît
Lamarche and Jean-François Mauger).
15. Insulin Resistance, Hypertension and Endothelial Dysfunction
(Stephen J. Cleland and John M. C. Connell).
16. Insulin Resistance and Polycystic Ovary Syndrome (Neus
Potau).
17. Syndromes of Severe Insulin Resistance (SSIRs) (David
Savage and Stephen O’Rahilly).
18. Therapeutic Strategies for Insulin Resistance (Harpal S.
Randeva, Margaret Clarke and Sudhesh Kumar).
19. Drug Therapy for Insulin Resistance – a Look at the
Future (Bei B. Zhang and David E. Moller).
Index.
Circa l’autore
Dr Sudhesh Kumar MD FRCP, Professor of Medicine (Diabetes &? Metabolism), Warwick Medical School, University of Warwick
Prof Steve O’Rahilly, Departments of Medicine and Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK
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