Table of Content
Frontmatter — Preface — Contents — I. Methods of Gene Delivery — 1. Retroviral Vectors — 2. Adenoviral Vectors — 3. Herpes Simplex Virus Mediated Gene Transfer to Neurons — 4. Adeno-Associated Viral Vectors — 5. Virus Functions for Artificial Vectors — 6. Targeted Gene Delivery and Expression in Hepatocytes — 7. Particle-Mediated Gene Delivery System for Cancer Research — II. Methods for Inactivation or Restoration of Gene Function — 8. Gene Inactivation by Homologous Recombination – Animal Models of Plasma Lipoprotein Disorders — 9. Potential Antisense Oligonucleotide Therapies for Neurodegenerative Diseases — 10. Synthetic Ribozymes: The Hammerhead Ribozyme — 11. Ribozymes as Tools for the Gene Therapist — III. Cellular Target Systems — 12. Gene Transfer and Transgene Expression in Hematopoietic Cells — 13. The Liver as a Target for Gene Therapy — 14. Gene Therapy for Gaucher Disease via Genetically Engineered Primary Myoblasts — 15. In vivo Secretion of Therapeutic Proteins from Neo-Organs — IV. Genetic Diseases — 16. Gene Therapy for Cystic Fibrosis – Strategies, Problems and Perspectives — 17. Gene Therapy for Dystrophin Deficiency — 18. Gene Therapy For Familial Hypercholesterolemia — 19. Therapeutic Strategies for the Lysosomal Storage Disorders — V. Non-Genetic and Infectious Diseases — 20. Gene Therapy for Arthritis — 21. Gene Therapy for HIV-1 Disease — VI. Cancer — 22. Suicide Genes for the Treatment of Cancer — 23. Tumor Cell Vaccines Using Genetically Modified Cells Coexpressing Cytokines and the T Cell Costimulatory Molecule B7 — 24. Dosage Impact on Immunotherapy with Cytokine-Gene Modified Cancer Vaccines — 25. Tumor Suppressor Gene Therapy – Growth Arrest and Programmed Cell Death — Acknowledgement — References — Contributors — Index
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