Gregory R. Bock & Jamie A. Goode 
Immunological Tolerance [PDF ebook] 

This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.

Inhoudsopgave

Introduction (Mitchison).

Mechanisms of peripheral T cell tolerance (L. Parijs, et
al.).

B cell antigen receptor signalling in the balance of tolerance
and immunity (Cirnall and FGoodnow).

General discussion I.

The study of self-tolerance using murine haemoglobin as a model
self antigen (Williams and Allen).

Tolerance and determinant hierarchy (Schnieder et al).

Molecular genetic studies in lymphocyte apoptosis and human
autoimmunity (Martin, et al.).

General discussion II.

A Role for CTLA-4-mediated inhibitory signals in peripheral T
Cell tolerance? (Allison, et al).

Antigen-specific CD4¯+ Tcells that survive after the
induction of peripheral tolerance possess an intrinsic lymphokine
production defect (pape et al).

Antigen-specific tolerance induction and the immunotherapy of
experimental autoimmunity disease (Anderton, et al.).

Quantitative and qualitative control of antigen receptor
signalling in tolerant B lymphocytes (Healy, et al.).

Tolerance induction with CD4 monoclonal antibodies (Waldmann et
al).

Cross-presentation of self antigens to CD8¯+ Tcells:
the balance between tolerance and autoimmunity (Kurts et al).

General discussion III.

Tolerance induction in mature T lymphocytes (Alferink, et
al.).

T lymphocyte-mediated control of autoimmunity (E. Shevach, et
al.).

Final General Discussion.

Indexes.

Over de auteur

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