This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Cuprins
Introduction (Mitchison).
Mechanisms of peripheral T cell tolerance (L. Parijs, et
al.).
B cell antigen receptor signalling in the balance of tolerance
and immunity (Cirnall and FGoodnow).
General discussion I.
The study of self-tolerance using murine haemoglobin as a model
self antigen (Williams and Allen).
Tolerance and determinant hierarchy (Schnieder et al).
Molecular genetic studies in lymphocyte apoptosis and human
autoimmunity (Martin, et al.).
General discussion II.
A Role for CTLA-4-mediated inhibitory signals in peripheral T
Cell tolerance? (Allison, et al).
Antigen-specific CD4¯+ Tcells that survive after the
induction of peripheral tolerance possess an intrinsic lymphokine
production defect (pape et al).
Antigen-specific tolerance induction and the immunotherapy of
experimental autoimmunity disease (Anderton, et al.).
Quantitative and qualitative control of antigen receptor
signalling in tolerant B lymphocytes (Healy, et al.).
Tolerance induction with CD4 monoclonal antibodies (Waldmann et
al).
Cross-presentation of self antigens to CD8¯+ Tcells:
the balance between tolerance and autoimmunity (Kurts et al).
General discussion III.
Tolerance induction in mature T lymphocytes (Alferink, et
al.).
T lymphocyte-mediated control of autoimmunity (E. Shevach, et
al.).
Final General Discussion.
Indexes.
Despre autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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