This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Spis treści
Introduction (Mitchison).
Mechanisms of peripheral T cell tolerance (L. Parijs, et
al.).
B cell antigen receptor signalling in the balance of tolerance
and immunity (Cirnall and FGoodnow).
General discussion I.
The study of self-tolerance using murine haemoglobin as a model
self antigen (Williams and Allen).
Tolerance and determinant hierarchy (Schnieder et al).
Molecular genetic studies in lymphocyte apoptosis and human
autoimmunity (Martin, et al.).
General discussion II.
A Role for CTLA-4-mediated inhibitory signals in peripheral T
Cell tolerance? (Allison, et al).
Antigen-specific CD4¯+ Tcells that survive after the
induction of peripheral tolerance possess an intrinsic lymphokine
production defect (pape et al).
Antigen-specific tolerance induction and the immunotherapy of
experimental autoimmunity disease (Anderton, et al.).
Quantitative and qualitative control of antigen receptor
signalling in tolerant B lymphocytes (Healy, et al.).
Tolerance induction with CD4 monoclonal antibodies (Waldmann et
al).
Cross-presentation of self antigens to CD8¯+ Tcells:
the balance between tolerance and autoimmunity (Kurts et al).
General discussion III.
Tolerance induction in mature T lymphocytes (Alferink, et
al.).
T lymphocyte-mediated control of autoimmunity (E. Shevach, et
al.).
Final General Discussion.
Indexes.
O autorze
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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